Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria

Document Type : Original Article

Authors

1 Chemistry department, Faculty of Science, Alexandria University

2 Pharos University in Alexandria

3 Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

4 Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia

5 Department of Botany & Microbiology, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

Abstract

Drug resistance is a major global problem leading to higher morbidity and mortality rates especially among hospitalized patients. Hence in the present study, 1,2,3-Triazole-acetophnone molecular conjugates 3a-c were resynthesized and then used in nanoformulated composites (3a-cCNPs) using chitosan as a matrix to give nano compounds of particle size ranging from 20 to 40 nm. Antimicrobial activity of the synthesized compounds and the nanoformulated analogues against multi-drug resistant microbes revealed that 3bCNPs was the most potent candidate due to its high efficiency against multi-drug resistant (MDR) microbes that reached complete microbial cells eradication after 4 hours. The synthesized nanoparticles were fully char-acterized through TEM, FTIR and XRD which proved the homogeneity of the synthesized nanoformula with particle size ranged between 20 to 40 nm. The present findings discovered novel antimicrobial activities that may have therapeutic potentials. This discovery may lead to an assumption that the tested compounds can be used as candidates in biomedical applications against drug resistant microbes.

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