An Overview of Medicinal Chemistry of Fluorine

Editor-in-Chief Lecture

Authors

1 Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

2 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States

3 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States. Medicinal Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

4 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States. Biotechnology & Life Sciences Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62517, Egypt

5 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States; Department of Chemistry, University of Delhi, Delhi 110007, India

6 Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47906, United States; Department of Chemistry, Purdue University, West Lafayette, Indiana 47906, United States

Abstract

Many drugs contain fluorine atoms or fluorine-containing groups. Fluorinated functional groups are typically used by the medicinal chemistry communities to influence the physicochemical, pharmacokinetic, and pharmacodynamic properties of small molecules. This lecture aims to illustrate the effect of fluorine on compounds at the physicochemical level, and its consequent impact on pharmacological properties, using practical examples. The lecture will also be highlighting a recent research about Co-catalytic Hydrothiolation of gem-Difluoroalkenes.

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Alexandria Journal of Science and Technology
Volume 3, Issue 2 - Serial Number 2
Special Issue (Conference Presentations): The Role of Organic, Medicinal, and Pharmaceutical Chemistry in Small Molecule Discovery for Biomedical Applications
September 2025
Pages 132-132

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